Because it is an immune-mediated disease of the thyroid, HT does not have a significant impact on the overall cancer incidence in affected individuals, but it can lead to a pro-inflammatory state, and the elevated levels of thyroid-stimulating hormone (TSH) may contribute to the development of PTC by affecting the TSH receptor, which may play a role in the development of cancer (12–14). This evidence concerns the gene TSHR and cancer.