Conversely, studies have also found that in systemic lupus erythematosus (SLE), loss of PGRN reduces Th1, Th17, IFN-γ, and IL-17A levels, whereas it increases Th2, Treg, Breg, IL-4, and IL-10 levels. The gene discussed is IL17A; the disease is systemic lupus erythematosus.