XDH and metabolic dysfunction-associated steatotic liver disease: A growing body of observational data points to a significant association between serum uric acid (SUA) levels and the risk of NAFLD.7,8 The main end product of purine metabolism is uric acid, and an imbalance between uric acid production and excretion can lead to excessive levels of SUA in the body.9 According to several human investigations, NAFLD patients have high serum levels of the enzyme xanthine oxido reductase, which catalyzes the production of uric acid, and this enhanced production of uric acid can speed up the progression of NAFLD.