Albumin reduces the phosphorylation of retinoblastoma protein and increases expression of p21 and p57 which causes the proliferation of G0/G1 cell population in the liver thereby slowing the spread of HCC.42 An additional function of albumin is immunomodulation which causes macrophage activation and triggers cell-mediated immunity against cancer cells.7 The second component of GNRI is body weight which is calculated as the ratio of current body weight to ideal body weight. The gene discussed is ALB; the disease is cancer.