Other researchers found that cardiovascular risks is directly proportional to systolic and diastolic BP.19 Patients with low ejection fraction (EF) have higher mortality and more frequent major cardiac events as compared to those with EF=66% or above as reported by Liu et al, 2022.20 The study reported the CC genotype in A1166C polymorphism of the AGTR1 gene variability as an inducer of endothelium associated abnormalities in structural and functional heart condition among individuals who had arterial hypertension.21 The gene discussed is AGTR1; the disease is Hypertension.