[42] used LIPUS (500 kHz) to stimulate the ischemic hemisphere of MCAO mice, which induced microglial cell polarization toward M2 and up-regulated IL-10/IL-10R signaling, resulting in an improvement of the neurological prognosis and a reduction of the volume of brain atrophy on days 7 to 14 after the operation. Here, IL10RA is linked to Brain atrophy.