For instance, glycolytic enzymes Phosphofructokinase 1 and Enolase 1 have been found to directly bind to transcription factors and induce the expression of target genes, whereas Aldolase A and Lactate Dehydrogenase A take part in various epigenetic processes through protein interactions.41, 42, 43, 44 In addition, Pyruvate Kinase M2 and phosphoenolpyruvate carboxykinase 1 can act as kinases and contribute to tumor progression by phosphorylating and modifying substrate proteins.45 The gene discussed is PCK1; the disease is neoplasm.