MYC and cancer: As a pleiotropic transcription factor, the oncoprotein MYC controls global gene expression involved in many cellular processes, including metabolism, proliferation, senescence, cell metastasis, programmed cell death, angiogenesis, and ribosomal and protein biogenesis.4, 5, 6, 7, 8, 9, 10 In addition, MYC enables cancer cells to escape immune monitor through various methods.11