The immune cells infiltrated in tumor microenvironment include tumor-associated macrophages, dendritic cells, myeloid-derived suppressor cells, T cells, B cells, natural killer cells, neutrophils, etc. 94Upon the activation of MYC, not only more macrophages are infiltrated into the tumor, but also T, B, and natural killer cells are excluded from the tumor microenvironment.89 This evidence concerns the gene MYC and neoplasm.