However, MYC is abnormally expressed in almost 70% of human malignancies.7, 8, 9 Numerous mechanisms, such as gene amplification, chromosomal translocation, retroviral insertion, activation of super enhancers, elevated cell signaling, and post-translational pathways, contribute to the abnormal activation of MYC in cancer cells.36, 37, 38, 39, 40 Genomic alterations, such as gene amplification and chromosomal translocations, can lead to increased MYC expression.40 Here, MYC is linked to cancer.