Sun et al developed two small molecules HA-1141 and HA-9104 that targeted F56 and V30 of UBE2F-UBA3 binding pockets on the UBE2F surface, which then restrains the neddylation modification of CUL5.122, 123, 124, 125 These two UBE2F inhibitors could effectively induce apoptosis and G2/M arrest, which probably are further developed into anti-cancer reagents.125. Here, CUL5 is linked to cancer.