MAT2A and Hepatic fibrosis: HuR modification by NEDD8 protects HuR from proteasomal degradation, allowing HuR to exert post-transcriptional modification, which promotes the accumulation of methionine adenosyltransferase 2A (MAT2A) mRNA in hepatocytes, leading to the malignant transformation of hepatocytes, as well as exerts apoptosis-controlling effects by stabilizing herpesvirus-associated ubiquitin-specific protease (MAT2A) mRNA and activates hepatic stellate cells to promote hepatic fibrosis by stabilizing α-SMA mRNA.87