GEO database analysis revealed that high expression of UBE2M was associated with multiple metastasis, microvascular infiltration, and immune evasion in HCC patients, leading to a worse overall survival.111, 112, 113 Thus, the drugs targeting E2s to disrupt the interaction between E2 and E1 or E2 and E3, show a great effect in tumor suppression.114. This evidence concerns the gene UBE2M and neoplasm.