NEDD8 and hepatocellular carcinoma: While the ubiquitin sites of SREBP-1c can also conjugate with a NEDD8 molecule to compete with ubiquitin in the context of neddylation overexpression, neddylation of SREBP-1 stabilizes its protein levels and allows it to continue exerting its transcriptional activity and promotes the production of fatty acids and the development of metabolic-associated fatty liver disease-related HCC.41