TNF and neoplasm: Simultaneously, compared with the control group, the combination treatment group exhibited a significantly higher frequency of TNF-α+ IFN-γ+ CD8+ T cells in the dLNs (Fig. S3B), as well as increased proportion and absolute number of IFN-γ+ and GZMB+ CD8+ T cells in tumor-infiltrating lymphocytes (Fig. S3C, D).