In PM2.5-induced lung cancer, circCDR1as specifically binds to splicing factor 1 rich in serine/arginine (SRSF1), affecting SRSF1's splicing of VEGFA mRNA and ultimately inhibiting lung cancer cell apoptosis, thereby promoting the development of PM2.5-induced lung cancer.86 The gene discussed is SRSF1; the disease is lung carcinoma.