circNDUFB2 is also recognized by retinoic acid-inducible gene I (RIG-I) to activate RIG-I–MAVS (mitochondrial antiviral-signaling) signaling cascades and recruit immune cells into the TME, participating in the degradation of IGF2BP and activation of anti-tumor immunity during non-small cell lung cancer progression.77 The gene discussed is RIGI; the disease is non-small cell lung carcinoma.