Previous studies have shown that SP1, as a target gene of circRNA, regulates gene transcription after indirect binding to circRNAs, including circZNF609 and circRNA_0005529, circSCAF11, and circRNA_0026,628, to promote cancer occurrence.32, 33, 34, 35 Song et al revealed that in addition to DNA binding ability, SP1 also directly binds to RNA in vivo.36 Here, SP1 is linked to cancer.