,76 For example, in non-small cell lung cancer, circNDUFB2 acts as a scaffold, interacting with the tripartite motif-containing 25 (TRIM25) and insulin-like growth factor 2 mRNA-binding protein (IGF2BP) to form a ternary complex that promotes IGF2BP ubiquitination and degradation; this process is enhanced by m6A modification of circNDUFB2.77 The gene discussed is TRIM25; the disease is non-small cell lung carcinoma.