As for metastasis, transforming growth factor beta 1 (TGFβ1) upregulates ACSL3 responsible for the first step of FAO through the SREBP1 signaling pathway and levels of FAO, mediating epithelial mesenchymal transformation (EMT) as well as metastasis of CRC cells while maintaining redox homeostasis.69 Here, TGFB1 is linked to colorectal carcinoma.