However, confusingly, some studies have found that the down-regulation of FAO-related protein CPT1B contributes to high-grade bladder cancer, vice versa, overexpression of CPT1B in high-grade bladder cancer cells can reduce EMT in vitro, and diminish cell proliferation, EMT and metastasis in vivo.80 This evidence concerns the gene CPT1B and urinary bladder carcinoma.