SIRT4 and colorectal carcinoma: In this context, considering the roles of Cnt, C2Cnt, and SIRT4 in cancer cellular metabolism, the present study aims to evaluate the effects of Cnt and C2Cnt on CRC cell lines, focusing on their potential influence on metabolic pathways in order to deepen the understanding of the CRC molecular mechanism(s) and identify new strategies for targeting the metabolic vulnerabilities of CRC.