The role of carnitines has been widely explored in cancer cachexia, where Cnt and C2Cnt supplementation has shown beneficial effects through reducing the serum concentrations of the cytokines inteleukin (IL)-6 and tumor necrosis factor (TNF)-α and the downstream molecules of the NF-κB and Cox-2 inflammatory pathways [52,53,54,55]. The gene discussed is TNF; the disease is cancer.