TLR4 and ulcerative colitis: Ulcerative colitis and allergic rhinitis: In the treatment of ulcerative colitis (UC), Shao et al. demonstrated that higenamine can inhibit the Galectin-3/TLR4/NF-κB signaling pathway in UC mice [57], improve the viability and epithelial barrier function of normal human colon epithelial cells (NCM460) induced by sodium dextran sulfate, and inhibit cell apoptosis and inflammation [57].