Interestingly, following FKBP5 knockdown, HSD11B1 levels were upregulated by DEX in these 3 cells, but the increases were substantially lower than those seen in control siRNA-transfected cells: 1.7-fold in normal myometrial cells (P < .05), 1.4-fold in HESCs (P < .05), and 2.5-fold in leiomyoma cells (P < .05). This evidence concerns the gene HSD11B1 and leiomyoma.