Thus, to better understand the dysregulation of FKBP51-GR signaling in the pathogenesis of leiomyoma, we focused on downstream regulation of hydroxysteroid 11-β dehydrogenase 1 (HSD11β1) in normal myometrium vs leiomyoma tissues and found increased HSD11β1 expression in leiomyoma samples compared to normal myometrium. This evidence concerns the gene FKBP4 and leiomyoma.