To elucidate how elevated FKBP51-GR signaling contributes to the pathogenesis of leiomyomas, we compared the expression of genes encoding ECM proteins (LAMA2, LAMB1, and FN1) and genes associated with smooth muscle cell proteins (CNN1, MYH9, MYH10, ACTA2) in cultured leiomyoma cells transfected with control vs FKBP5 siRNA and treated with DEX. This evidence concerns the gene ACTA2 and leiomyoma.