Pathogenic variants of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene, which encodes the alpha subunit of the voltage-gated sodium channel Nav1.1, lead to impaired inhibitory interneuron function, which results in neuronal hyperexcitability and severe epileptic syndromes, such as Dravet syndrome (DS) [42]. Here, SCN1A is linked to epilepsy syndrome.