Since 17,18-EEQ or 19,20-EDP combined with t-TUCB delivered via osmotic pumps also showed the suppression of NFκB activation induced by high-fat diet-induced obesity in the iBAT [10], the effects of either EpFA alone or with t-TUCB were further investigated on lipopolysaccharide (LPS)-induced NFκB activation in brown preadipocytes (Figure 5B). Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.