PNPLA3 and metabolic dysfunction-associated steatotic liver disease: It is interesting to note that a prospective study involving 452 patients with the human patatin-like phospholipase domain-containing three genes (PNPLA3), which is recognized as the key genetic determinant of NAFLD, reported an inverse association between the consumption of isoflavone-rich foods and the risk of severe fibrosis (stage of fibrosis ≥ 2) amongst carriers of the rs738409 G-allele [54].