INS and metabolic dysfunction-associated steatotic liver disease: Furthermore, a combination therapy of flaxseed and hesperidin (30 g + 1000 mg/day) for 12 weeks decreased plasma triglycerides (MD = −45.19 mg/dL), total cholesterol (MD = −26.53 mg/dL), fasting glucose (MD = −6.12 mg/dL), and indices of HOMA-IR (MD = −1.51) and insulin (MD = −3.17 mU/L) in NAFLD patients [73].