MAPK1 and Alzheimer disease: To characterize the BP and pathways that were significantly associated with TSPO PET binding, we performed enrichment analysis on DEPs as a function of TSPO PET positivity (LIMMA model, with a p < 0.01), unveiling BP that have been repeatedly reported as being associated to AD, such as positive regulation of MAPK cascade (Padj = < 0.0001), positive regulation of ERK1 and ERK2 cascade (Padj = < 0.0001), cytokine‐mediated signaling pathway (Padj = < 0.0001), and leukocyte migration (Padj = < 0.0001) as shown in Figure 2B,C.