Processes such as the positive regulation of MAPK cascade, highly involved with microglia‐mediated neuroinflammation in AD,50, 51 positive regulation of ERK1 and ERK2 cascade, suggested to be one of the most upregulated phosphoproteins within the MAPK pathway,52, 53 cytokine‐mediated signaling pathway,54, 55 and leukocyte migration56 have been repeatedly implicated in AD pathology, highlighting the interconnection between inflammation and neuronal dysfunction in the disease. This evidence concerns the gene MAPK1 and Alzheimer disease.