Among APOE ε4 carriers, the association between AFR proportion and cognitive outcomes (Clinical Dementia Rating Sum of Boxes) disappeared, indicating that the impact of APOE genotype on AD neuropathology and cognitive function is significantly influenced by ancestry, with non‐European APOE backgrounds showing lower neuropsychiatric burden but worse cognitive outcomes compared to European APOE backgrounds. This evidence concerns the gene APOE and Alzheimer disease.