The analysis revealed that ANPEP (IVW model: OR = 1.038, p < 0.001), STK11 (IVW model: OR = 1.1, p < 0.001, ACACB (IVW model: OR = 1.038, p = 0.035), and RPS6KB (IVW model: OR = 1.216, p = 0.022) may be related to the risk of CKD onset. The gene discussed is STK11; the disease is chronic kidney disease.