In our study, up to 32.5% (27/83) of IBD patients with NMH presented with normal CRP levels; however, reg1α level still presented a favourable efficacy for MH monitoring in those patients with normal CRP levels, especially in phenotype of UC with 76.5% sensitivity, 71.4% specificity, 71.9% accuracy. The gene discussed is REG1A; the disease is inflammatory bowel disease.