Considering the unique role of NGF in intestinal inflammation, where it not only participates in pain sensitisation but also mediates epithelial barrier repair via the TrkA receptor, we speculate that PMS may indirectly affect the biological effects of the NGF/TrkA signalling pathway by modulating the dynamic balance between pro‐inflammatory and anti‐inflammatory factors. This evidence concerns the gene NTRK1 and premenstrual tension.