JAK2 and obesity due to melanocortin 4 receptor deficiency: As for the differences, the potential pathogenesis of GLM is as follows: α1‐antitrypsin deficiency, oral contraceptives, microbiological agents, ethnicity, gestation, birth, and breastfeeding, while the pathogenesis of PCM is these points: the activation of IL‐6/JAK2/STAT3 pathway, anaerobic infection, overweight/obesity, and the late onset of menarche [52, 53, 54].