GSDMD and gout: The anti-inflammatoryevaluation of 83 in the MSU-induced gout model demonstratedits protective role in joint inflammation by decreasing inflammatoryfactor release and cell pyroptosis through the NOD-like receptor familypyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway.135 In addition, the high potency, neutral character,high selectivity, oral bioactivity, and improved PK/PD profiles ofcompound 83 are promising for further progress.