AR-C118925 is the most used pharmacologicaltool for invitro and in vivo studies of the P2Y2R. The commercial availability of this compound has facilitatednumerous studies to understand the therapeutic potential of the P2Y2R. Unsurprisingly, these studies reiterate P2Y2R’s relevance and potential applications in various inflammatoryconditions and cancer. The gene discussed is P2RY2; the disease is cancer.