Recent studies have found that FTO is a key regulator in the development of neurological disorders including Alzheimer’s disease,46 Parkinson’s disease,19 fragile X syndrome, and depression.47 A study by Li et al. confirmed the relationship between FTO and neuropathic pain.23 Peripheral nerve injury leads to a significant increase in FTO in the injured DRG, which contributes to the induction and maintenance of nerve-injury-induced neuropathic pain at least in part through erasing the m6A in Ehmt2 mRNA and stabilizing the nerve-injury-induced Ehmt2 mRNA/G9a increase in the injured DRG. This evidence concerns the gene EHMT2 and depressive disorder.