Molecular confirmation of the NF1 was essential to avoid misdiagnosing NF-NS as other RASopathies with overlapping features, such as café-au-lait spots and lentigines, seen in Legius syndrome [67], NS [68], NS with multiple lentigines [68], and heterozygous LZTR1 variants [69]. Here, LZTR1 is linked to neurofibromatosis-Noonan syndrome.