ACAT1 and neoplasm: Consequently, bioluminescence images and hematoxylin and eosin (H&E) staining of tumor tissues indicated that despite the identical mitochondrial level of ACAT1 in the WT and NES groups, the antitumor capacity was deprived in NES group; moreover, tumor growth was impaired in NLS group (Fig. 2f and Supplementary Fig. 2j).