To elucidate the clinical significance of our findings that ACAT1 pS60 facilitates NK cell infiltration and activation, IF analysis with anti-ACAT1, anti-COX IV antibodies and IHC analysis with anti-ACAT1 pS60, anti-PPM1A, and anti-NCR1 antibodies were performed on tumor tissues from patients with CRC. The gene discussed is COX4I1; the disease is neoplasm.