ACAT1 and neoplasm: To date, studies on ACAT1 have focused mainly on its mitochondrial function.28,29,36,37 Intriguingly, we observed that ACAT1 was located not only in mitochondrion but also in the nucleus (Fig. 2a, Supplementary Fig. 2a) and the level of nuclear ACAT1 was noticeably lower in tumor tissues than in the paired peritumoral tissues (Fig. 2b).