Furthermore, subcutaneous tumor model revealed that mp50 K144Q (equivalent to K146Q in humans) clearly restricted tumor growth (Fig. 4i) and elevated the percentages of cytotoxic NK cells but not CD4+ or CD8+ T cells in tumors (Fig. 4j and Supplementary Fig. 5k), indicating that the antitumor capacity of p50 K146ac relies on NK cell activation. This evidence concerns the gene CD8A and neoplasm.