AOC3 and colorectal carcinoma: The immune-related functions of the two top-ranked metabolic enzymes—glutathione S-transferase mu 2 (GSTM2) and amine oxidase, copper containing-3 (AOC3)—have been widely discussed, indicating the reliability of our analytical method.32–35 However, the effect of the metabolic enzyme ACAT1 on the immune microenvironment in CRC remains unknown.