MSX1 and tooth agenesis: Tooth agenesis presents a significant clinical challenge due to the multifaceted nature of its causes and manifestations.33,34 Mutations in the Msx1 gene have been implicated in halting tooth morphogenesis at the bud stage, indicating its potential role as a pathogenic gene for tooth agenesis.35 Loss-of-function mutations in genes such as PAX9 and WNT10A have also been associated with familial tooth agenesis (FTA).36 In our current investigation, we observed that miR-206 effectively reversed dental developmental abnormalities resulting from KDM2B upregulation.