Siglec-10, an IC, is capable of recognizing both surface proteins (e.g., CD24) and surface sialic acids.19 Upon binding of CD24 to Siglec-10, an inhibitory signaling cascade occurs to prevent macrophage phagocytosis and promote tumor growth.19 We next tested whether de-N-glycosylated CD24 could also bind to Siglec-10. The gene discussed is CD24; the disease is neoplasm.