Our data revealed that effective FBL depletion in PDXs by lentivirus significantly inhibited tumor growth (Fig. 6A–D), along with a significant decrease in Ki67-positive malignant cells in FBL-knockdown tumors, indicating impaired cell proliferation upon FBL depletion (Figs. S9A, B and 6E). The gene discussed is FBL; the disease is neoplasm.