Increased gene expression of HMGCR was associated with an elevated risk of cystic kidney disease (IVW-MR: odds ratio [OR] = 3.05, 95% confidence interval [CI] = 1.19–7.84, p = 0.02) and PKD (IVW-MR: OR = 2.13, 95% CI = 1.01–4.46; p = 0.045). Here, HMGCR is linked to cystic kidney disease.