A growing number of Kv3.1, Kv3.2, and Kv3.3 variants have been linked to a spectrum of severe encephalopathies and psychiatric disorders, and mapped on the structure of hKv3.1a and models of Kv3.2 (Chi et al., 2022; Faulkner et al., 2024; Gunthorpe, 2022; Schwarz et al., 2022). This evidence concerns the gene KCNC2 and psychiatric disorder.