We found that improved fibrosis resolution in KO mice was alcohol specific, because we did not observe C/EBPβ-mediated fibrosis resolution in a metabolic dysfunction–associated steatotic liver disease model, and it was associated with changes in cholesterol/bile acid metabolism and increased expression of the CYP3A family of enzymes, suggesting that these pathways might be involved in fibrosis resolution. This evidence concerns the gene CYP3A4 and liver disorder.