To confirm the inhibition of tumor growth associated with decreased chemokine expression in Ccn1‐KO tumor, we focused on CXC chemokines, including CXCL1, CXCL3, and CXCL5, which bind to CXCR2, as well as CCL2 and CCL7, which bind to CCR2. This evidence concerns the gene CCL2 and neoplasm.