Previous studies have shown that selective deletion of type I collagen (Col1) in pancreatic cancer myofibroblasts leads to the upregulation of Cxcl5 in cancer cells and suppression of CD8+ T cells.[36] To investigate whether Ccn1 promotes chemokine expression through the regulation of collagen, we examined the effects of Col5a1 overexpression in Ccn1‐deficient KPC cells. This evidence concerns the gene CCN1 and pancreatic neoplasm.