In tumor cells, hyperactivated signal transducer and activator of transcription 3 (STAT3) can downregulate the expression of immune‐stimulating factors such as interferons while increasing the expression of cytokines like IL6 and IL10, thereby exerting significant immune effects.[44] We observed that the level of STAT3 phosphorylation in Ccn1‐deficient KPC cells was lower than that in the control group when treated with IFNγ (Figure 5L). This evidence concerns the gene IL6 and neoplasm.