These chemokines regulate the infiltration and migration of various immune cells, such as monocytes, memory T lymphocytes, and NK cells, which play critical roles in the immune response.[34, 35] Inoculation of Ccn1‐KO KPC and control cells into the subcutaneous flank of C57BL/6J mice, followed by treatment with SB225002 (a selective CXCR2 antagonist) and RS504393 (an antagonist of CCR2), revealed that tumor volume decreased significantly with CCR2 inhibitor or combined treatment in the control group pancreatic tumors (Figure4A,B). Here, CCN1 is linked to neoplasm.