In tumor cells, hyperactivated signal transducer and activator of transcription 3 (STAT3) can downregulate the expression of immune‐stimulating factors such as interferons while increasing the expression of cytokines like IL6 and IL10, thereby exerting significant immune effects.[44] We observed that the level of STAT3 phosphorylation in Ccn1‐deficient KPC cells was lower than that in the control group when treated with IFNγ (Figure 5L). The gene discussed is IL10; the disease is neoplasm.