ITGA6 functions as an HPV receptor and has been linked to therapy resistance in HNSCC, making it an especially intriguing target in HNSCC [35, 36] In the cancer genome atlas (TCGA) dataset of HNSCC patients, ITGA3, ITGA5, and ITGA6 all show prognostic resolution [37]. Here, ITGA3 is linked to head and neck squamous cell carcinoma.