Interestingly, plasma NfL levels showed a positive correlation with disease progression rate (ΔFS) (ANOVA test, p = 0.0032) (Fig. 6F) and a negative correlation with the ALS-specific ECAS score (ANOVA test, p = 0.0090) (Supplementary Table 3, Additional File 3). Here, NEFL is linked to amyotrophic lateral sclerosis.