However, TDP-43 pathology is also observed in other neurodegenerative diseases, including frontotemporal lobar degeneration with TDP-43-immunoreactive pathology (FTLD-TDP) [13], Perry disease [14], limbic-predominant age-related TDP-43 encephalopathy (LATE) [15], sporadic inclusion body myositis (sIBM) [16], Alzheimer’s disease (AD) and hippocampal sclerosis [17], Parkinson’s disease (PD) [18], dementia with Lewy bodies (DLB) [19], multiple system atrophy (MSA) [20], corticobasal degeneration (CBD) [21], progressive supranuclear palsy (PSP) [22], and Huntington’s disease (HD) [23]. The gene discussed is TARDBP; the disease is Alzheimer disease.