DIDO1 and hematopoietic and lymphoid cell neoplasm: Remaining open questions include the DNA methylation and the overall histone PTM landscape in Dido3-deficient cells, as well as the consequences of Dido3 deficiency in peripheral B cell differentiation, although our findings already support the multifaceted role of Dido3 in B cell development and its broader implications in immune system development and hematopoietic cancer biology.