Analysis of postmortem brain tissue of PD patients revealed elevated levels of the key necroptotic proteins, including receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) (Iannielli et al. 2018).. This evidence concerns the gene RIPK1 and Parkinson disease.