MATN3 and Fuchs endothelial corneal dystrophy: While guttae comprise multiple FECD-associated pathological ECM components, we focused on several key molecules: FN1, which has been well established in previous literature34–36, as well as LTBP2, MATN3, and BGN, which our previous shotgun proteomic analysis identified as upregulated genes in FECD patients37.