CYP11A1 and neoplasm: Importantly, steroidogenesis inhibition by deleting Cyp11a1 (Cyp11a1cKO mice) effectively countered these GC-induced alterations, as revealed by up-regulated genes from RNA-seq data, in tumour infiltrating DCs of Cyp11a1cKO tumour-bearing mice compared to control tumour bearing mice (Fig. 3J).