Observation of Cyp11a1-mCherry+ myeloid cells (macrophages/monocytes) in the tumour-bearing Cyp11a1-mCherry+ mice was consistent with the previous observation of colorectal cancer by Acharya et al., Immunity, 202054; but dissimilar with melanoma by Mahata et al., Nat Commun, 202033, where the percentage of Cyp11a1+ macrophages/monocytes were very low by number. Here, CYP11A1 is linked to neoplasm.