HSPG2 and malignant colon neoplasm: A growing body of evidence strongly support a pathogenic role for IL-17 in carcinoma formation, including cancers of the colon, skin, pancreas, liver, lung and myeloma, also PLC.40, 41 Analogously, TNF-α is also a commonly reported biomarker in rosacea,42 may promote proliferation, survival, migration, and angiogenesis of chemotherapy-resistant cancer cells, thus facilitating tumor development.