In subsequent multivariable Cox regression models adjusted for NT-ProBNP ratio ≥3 and STS score, a serum level of HE4 ≥130 pmol/L remained independently associated with a higher risk of all-cause mortality, the composite endpoint of rehospitalization for HF and all-cause mortality, and treatment futility (Supplemental Table 7). The gene discussed is NPPB; the disease is hydrops fetalis.