In multivariable analyses, a serum level of HE4 ≥130 pmol/L was independently associated with all-cause mortality (HR: 3.26 [95% CI: 2.04-5.20], P < 0.001) (Figure 1, Supplemental Table 3), rehospitalization for HF (sHR: 2.08 [95% CI: 1.04-4.04], P = 0.038) (Figure 2, Supplemental Table 4), the composite endpoint of rehospitalization for HF and all-cause mortality (HR: 2.48 [95% CI: 1.64-3.74], P < 0.001) (Figure 3, Supplemental Table 5), and treatment futility (HR: 2.99 [95% CI: 1.76-5.04], P < 0.001) (Supplemental Table 6). This evidence concerns the gene WFDC2 and hydrops fetalis.