In comparison with patients with lower serum levels of HE4, patients with higher serum levels had significantly higher rates of dialysis, new onset of atrial fibrillation, length of hospital stay, as well as higher rates of 30 days, 1-year all-cause mortality, cardiovascular mortality, and rehospitalization for HF (P < 0.001). The gene discussed is WFDC2; the disease is atrial fibrillation.