It was discovered that HIBCH is one of the proteins that is overexpressed in malignancies, such as ovarian tumours, and that is expressed differentially in mitochondria [30], Blocking 3‐hydroxyisobutyryl‐CoA hydrolase (HIBCH) to stop the breakdown of valine resulted in decreased intracellular succinate, a decrease in the development of cancerous prostate cells, and impaired cellular respiration [31]. Here, HIBCH is linked to ovarian neoplasm.