Further, it has been noticed that plumbagin suppresses the proliferation and survival of esophageal cancer cells and human bladder cancer cells via STAT3-PLK1-AKT and P13K/AKT/mTOR signaling pathways and epithelial–mesenchymal transition (EMT), respectively [98,105,106]. Here, AKT1 is linked to urinary bladder carcinoma.