This alkaloid suppresses cancer cell migration (T98G cell line) and inhibits cell proliferation (U87MG and T98G cell lines) by inhibiting HMGB1 (high-mobility group box 1 protein, which is involved in cell migration and tumor metastasis) and RAGE (receptor for advanced glycation end products, which plays a role in tumor cell growth, migration, and invasion). Here, HMGB1 is linked to neoplasm.