PDK3 and glioblastoma: Inhibiting aerobic glycolysis, excessively activates mitochondrial respiration and promotes production of ROS (229R cells)IC50 = 2.17 μM (in 229R cells)IC50 = 2.39 μM (in 251R cells)Inhibiting the proliferation and invasive capacity of chemoresistant GBM cells (in dose-dependent manner, at 1 μM, 2 μM, and 4 μM)Inhibiting the chemoresistant GBM cell growth and lactate production in vivo (30 mg/kg/day)Inhibiting PDK3 expression in vitro and in vivoSupressing the aerobic glycolysis and oxidative phosphorylation hyperactivation by inhibiting PDK3