JAK2 and central nervous system cancer: Inhibiting the proliferation of glioma cells: IC50 concentration for nitidine was between 5.0 and 7.5 μM (48 h)Inhibiting the migration and invasion abilities in glioma cells (in a concentration-dependent manner)Upregulation of the expression of epithelial marker E- cadherin at concentrations > 7.5 μMPromoting the glioma cell apoptosis in a concentration-dependent manner (2.5, 5.0, 7.5, and 10.0 μM) for 48 hInhibiting the JAK2/STAT3 pathwayInhibiting the enhanced expression of stem cell markers