ATF3 and central nervous system cancer: Inhibiting the viabilities of human U251, U87, U118, and A172 glioma cells in a dosage-dependent manner (from 50 to 800 μmol/L)Could obviously inhibit the U87 and U251 glioma cells to form colonies (12.5–25 μM brucine)Inducing the upregulation of the activating transcription factor 3 (ATF3)Improving the ferrous iron and lipid peroxidation in glioma cells in a dosage- and time-dependent manner of brucine (250–500 μM)Inducing the generation of malondialdehyde (MDA)Inducing the ferrous iron-dependent lipid peroxidation and glioma cell death