MKI67 and neoplasm: Binding to the intracellular EGFR (696-1022) domain as an inhibitor of EGFR (IC50 was about 68 nM)IC50 = about 10 μM (U251 cells)Decreasing of GBM cellular proliferation (10–20 μM)Decreasing the cell migration (in a dose-dependent manner)Inhibiting the colony formation (at 10 μM)Inducing cell apoptosis in an EGFR-mediated mannerInhibiting the xenograft tumor growths in three animal models in vivo (at 20 mg/kg/day of lycorine completely blocked the growth of tumor in mice)At 25 μM fully blocked EGFR phosphorylationDecreasing the expression of mRNA of EGF, EGFR, Bcl-xL, Ki-67, and protein level