Anti-proliferation effect in dose- and time-dependent manners (80, 120, 160 μM)Inducing the apoptosis, and mitochondrial damage in GBM cellsInducing the mitochondrial translocation of cofilin,Activation of cleaved- caspase3Degradation of PARP with formation of cleaved PARPInducing the autophagy associated with the AKT/mTOR pathway. This evidence concerns the gene CFL1 and glioblastoma.