Recently, it was shown that chelerythrine reduces the protein expression of p-ERK1/2 and p-Smad2/3 and inhibits the TGF-β1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway, thereby decreasing glioblastoma progression in U251 and T98G cell lines [29]. The gene discussed is SMAD2; the disease is glioblastoma.