Senrung et al. [202] demonstrated that piperine can suppress neoangiogenesis induced by malignant glioma cells (U87) by interfering with the vascular endothelial growth factor (VEGF) signaling pathway, leading to a reduction in VEGFR-2 transcript levels and a decrease in VEGF-A expression. The gene discussed is VEGFA; the disease is malignant glioma.