SPARC and neoplasm: Furthermore, human serum albumin has the ability to accumulate in tumor tissues [30], and this effect is attributed to the effective interaction of albumin with the gp60 receptor, a vascular endothelial membrane protein, and SPARC, an extracellular matrix glycoprotein that is overexpressed in various tumor types and plays a key role in albumin transcytosis and promotes the local concentration of albumin-based nanocarriers loaded with therapeutic agent in tumors [31,32].