On the other hand, in more aggressive or poorly differentiated tumors, AR signaling could promote tumor progression in a role similar to that observed in human triple-negative breast cancer (TNBC), where ARs have been shown to interact with pathways such as the PI3K/AKT/mTOR axis to support tumor growth and metastasis [83,84,85,86]. Here, AKT1 is linked to neoplasm.