BCL2 and cancer: Confirming the review of the literature on primary bioactive pyrimidines as a model scaffold for the production of new anti-cancer medications, As revealed in Figure 17, MCL-1 is an anti-apoptotic member of the Bcl-2 family, while the Bcl-2 gene is known for its role in regulating apoptosis, and its overexpression can contribute to cancer cell survival.