ANXA5 and cancer: The above findings are in line with the results presented in the current work, showing extracts of S. aethiopis with a high content of rosmarinic acid having detrimental effects on A549 and Hep G2 cancer cells, mediated in Hep G2 cells by cell apoptosis shown by AO/EB and DAPI staining experiments and Annexin-V/propidium iodide-based flow cytometry, accompanied by the decreased migration capacity of the cancer cells as demonstrated by the wound-healing (scratch) assay.