CASP9 and cancer: Furthermore, it was shown that rosmarinic acid decreased the viability of human Hep G2 liver cancer cells in a dose-dependent manner while inducing cancer cell apoptosis, as demonstrated by AO/EB and DAPI staining of the cells and observed changes in the expression of the apoptosis-related proteins Bax and Bcl-2, complemented by the activation of caspase-3 and caspase-9, which prevented the migration and invasion of the Hep G2 cancer cells [51].